Abstract Treatment of cancer in children is increasingly successful but leaves many prepubertal boys suffering from infertility or subfertility later in life. A current strategy to preserve fertility in these boys is to cryopreserve a testicular biopsy prior to treatment … Read more
News Releases
Structural basis for mismatch surveillance by CRISPR–Cas9
Abstract CRISPR–Cas9 as a programmable genome editing tool is hindered by off-target DNA cleavage1,2,3,4, and the underlying mechanisms by which Cas9 recognizes mismatches are poorly understood5,6,7. Although Cas9 variants with greater discrimination against mismatches have been designed8,9,10, these suffer from … Read more
Biogenic metallic elements in the human brain?
Abstract The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing positively charged Cu+, Cu2+, Fe2+, and Fe3+ control key processes, catalyzing oxidative metabolism and neurotransmitter and neuropeptide production. Here, … Read more
Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mouse
Sinha, Whelan, Tobias, Avarbock, Stefanovski, Brinster. Biology of Reproduction, Volume 105, Issue 2, August 2021, Pages 503–518, https://doi.org/10.1093/biolre/ioab093 Published: 06 May 2021 Abstract Retinoic acid (RA) induces spermatogonial differentiation, but the mechanism by which it operates remains largely unknown. We developed … Read more
Identification of vaccine targets in pathogens and design of a vaccine using computational approaches
Nature Scientific Reports | (2021) 11:17626 Kamal Rawal, Robin Sinha, Bilal Ahmed Abbasi, Amit Chaudhary, Swarsat Kaushik Nath, Priya Kumari, P. Preeti, Devansh Saraf, Shachee Singh, Kartik Mishra, Pranjay Gupta, Astha Mishra, Trapti Sharma, Srijanee Gupt, Prashant Singh, Shriya Sood, … Read more
Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade
Sharmila Nair,1 Luciano Mazzoccoli,1 Arijita Jash,1 Jennifer Govero,1 Sachendra S. Bais,1 Tong Hu,1 Camila R. Fontes-Garfias,2 Chao Shan,2 Hideho Okada,3,4 Sujan Shresta,5 Jeremy N. Rich,6,7,8 Pei-Yong Shi,2,9,10 Michael S. Diamond,1,11,12,13 and Milan G. Chheda1,14 Published November 24, 2020 Abstract: Glioblastoma multiforme (GBM) is a fatal human cancer in part because GBM stem cells are … Read more
Biogenic metallic elements in the human brain?
James Everett, Frederik Lermyte, Jake Brooks, Vindy Tjendana-Tjhin, Germán Plascencia-Villa, Ian Hands-Portman, Jane M. Donnelly, Kharmen Billimoria, George Perry, Xiongwei Zhu, Peter J. Sadler, Peter B. O’Connor, Joanna F. Collingwood and Neil D. Telling Science Advances 09 Jun 2021: Vol. 7, … Read more
Thymic development of gut-microbiota-specific T cells
Abstract Humans and their microbiota have coevolved a mutually beneficial relationship, with the human host providing a hospitable environment for the microbes, and the microbiota providing many benefits including nutritional benefits and protection from pathogen infection1. Maintaining this relationship requires … Read more
NF1 mutation drives neuronal activity-dependent initiation of optic glioma
Nature, published online: 26 May 2021 Neurons have recently emerged as essential cellular constituents of the tumour microenvironment, and their activity has been shown to increase the growth of a diverse number of solid tumours. Although the role of neurons … Read more
Biomimetic nano drug delivery carriers for treating cardiovascular diseases
Key Points • Why do we need biomimicry? Which challenges does it aim to overcome? • Systemic delivery of free drugs has limitations. These limitations include rapid systemic clearance, inadequate levels of drug in the target tissue, poor solubility of … Read more
