The Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation has funded an ambitious initiative to overcome one of the most perplexing and frustrating mysteries of cancer treatment — how to prevent drug resistance. Patients treated for cancers can have … Read more
News Releases
A naturally occurring alternative to antibiotics? San Antonio Medical Foundation-funded research provides key assistance.
Phages, which live in the digestive tract, could treat bacterial infections if issues impacting effectiveness are solved. Research at UT Health San Antonio and UTSA is doing just that. Contact: Will Sansom, 210-567-2579, sansom@uthscsa.edu SAN ANTONIO (Aug. 30, 2023) — … Read more
A Polarity-Sensitive Far-Red Fluorescent Probe for Glucose Sensing through Skin
Lydia Colvin, Dandan Tu, Darin Dunlap, Alberto Rios, and Gerard Coté Abstract The field of glucose biosensors for diabetes management has been of great interest over the past 60 years. Continuous glucose monitoring (CGM) is important to continuously track the glucose level to provide better … Read more
RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2
Abstract Cas12a2 is a CRISPR-associated nuclease that performs RNA-guided, sequence-nonspecific degradation of single-stranded RNA, single-stranded DNA and double-stranded DNA following recognition of a complementary RNA target, culminating in abortive infection1. Here we report structures of Cas12a2 in binary, ternary and … Read more
Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor
Link to article https://www.cell.com/cell-reports/pdfExtended/S2211-1247(22)00535-6 Memorial Sloan Kettering Statement BRCA mutations have been implicated in pancreatic cancer, as well as breast and ovarian cancers. Dr. Iacobuzio-Donahue and her colleagues traced the BRCA2 gene back to the chimpanzee-human last common ancestor in … Read more
Reestablishment of spermatogenesis after more than 20 years of cryopreservation of rat spermatogonial stem cells reveals an important impact in differentiation capacity
Abstract Treatment of cancer in children is increasingly successful but leaves many prepubertal boys suffering from infertility or subfertility later in life. A current strategy to preserve fertility in these boys is to cryopreserve a testicular biopsy prior to treatment … Read more
Structural basis for mismatch surveillance by CRISPR–Cas9
Abstract CRISPR–Cas9 as a programmable genome editing tool is hindered by off-target DNA cleavage1,2,3,4, and the underlying mechanisms by which Cas9 recognizes mismatches are poorly understood5,6,7. Although Cas9 variants with greater discrimination against mismatches have been designed8,9,10, these suffer from … Read more
Biogenic metallic elements in the human brain?
Abstract The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing positively charged Cu+, Cu2+, Fe2+, and Fe3+ control key processes, catalyzing oxidative metabolism and neurotransmitter and neuropeptide production. Here, … Read more
Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mouse
Sinha, Whelan, Tobias, Avarbock, Stefanovski, Brinster. Biology of Reproduction, Volume 105, Issue 2, August 2021, Pages 503–518, https://doi.org/10.1093/biolre/ioab093 Published: 06 May 2021 Abstract Retinoic acid (RA) induces spermatogonial differentiation, but the mechanism by which it operates remains largely unknown. We developed … Read more
Identification of vaccine targets in pathogens and design of a vaccine using computational approaches
Nature Scientific Reports | (2021) 11:17626 Kamal Rawal, Robin Sinha, Bilal Ahmed Abbasi, Amit Chaudhary, Swarsat Kaushik Nath, Priya Kumari, P. Preeti, Devansh Saraf, Shachee Singh, Kartik Mishra, Pranjay Gupta, Astha Mishra, Trapti Sharma, Srijanee Gupt, Prashant Singh, Shriya Sood, … Read more
