Biomimetic nano drug delivery carriers for treating cardiovascular diseases

Key Points

•  Why do we need biomimicry? Which challenges does it aim to overcome?
•  Systemic delivery of free drugs has limitations. These limitations include rapid systemic clearance, inadequate levels of drug in the target tissue, poor solubility of some drugs, and increased off target toxicity.
•  Much effort has been invested into the development of different synthetic drug carriers. However, biomimetic carrier systems, inspired by the way different cells in our body behave, hold great therapeutic potential in addressing these challenges.
•  Several types of cells that interact with the vascular system, including erythrocytes, leukocytes, and thrombocytes, have inspired the design of new biomimetic carriers.
•  Inspired by native cells’ biological functions, biomimetic nano-carrier platforms possess favorable properties such as: longer circulation times, mononuclear phagocyte system (MPS) evasion, and favorable interactions with target cells.

Assaf Zinger PhD, John P. Cooke MD, PhD , Francesca Taraballi PhD

ScienceDirect, Volume 33, April 2021, 102360

Full Article

Funded in part by the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation