RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2
Abstract Cas12a2 is a CRISPR-associated nuclease that performs RNA-guided, sequence-nonspecific degradation of single-stranded RNA, single-stranded…
3 years ago
News Releases
Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor
Link to article https://www.cell.com/cell-reports/pdfExtended/S2211-1247(22)00535-6 Memorial Sloan Kettering Statement BRCA mutations have been implicated in pancreatic…
4 years ago
Reestablishment of spermatogenesis after more than 20 years of cryopreservation of rat spermatogonial stem cells reveals an important impact in differentiation capacity
Abstract Treatment of cancer in children is increasingly successful but leaves many prepubertal boys suffering…
4 years ago
Structural basis for mismatch surveillance by CRISPR–Cas9
Abstract CRISPR–Cas9 as a programmable genome editing tool is hindered by off-target DNA cleavage1,2,3,4, and…
4 years ago
Biogenic metallic elements in the human brain?
Abstract The chemistry of copper and iron plays a critical role in normal brain function.…
4 years ago
Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mouse
Sinha, Whelan, Tobias, Avarbock, Stefanovski, Brinster. Biology of Reproduction, Volume 105, Issue 2, August 2021,…
5 years ago
Identification of vaccine targets in pathogens and design of a vaccine using computational approaches
Nature Scientific Reports | (2021) 11:17626 Kamal Rawal, Robin Sinha, Bilal Ahmed Abbasi, Amit Chaudhary,…
5 years ago
Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade
Sharmila Nair,1 Luciano Mazzoccoli,1 Arijita Jash,1 Jennifer Govero,1 Sachendra S. Bais,1 Tong Hu,1 Camila R. Fontes-Garfias,2 Chao Shan,2 Hideho Okada,3,4 Sujan Shresta,5 Jeremy N. Rich,6,7,8 Pei-Yong…
5 years ago
Biogenic metallic elements in the human brain?
James Everett, Frederik Lermyte, Jake Brooks, Vindy Tjendana-Tjhin, Germán Plascencia-Villa, Ian Hands-Portman, Jane M. Donnelly,…
5 years ago
Thymic development of gut-microbiota-specific T cells
Abstract Humans and their microbiota have coevolved a mutually beneficial relationship, with the human host…
5 years ago