Sharmila Nair,1 Luciano Mazzoccoli,1 Arijita Jash,1 Jennifer Govero,1 Sachendra S. Bais,1 Tong Hu,1 Camila R. Fontes-Garfias,2 Chao Shan,2 Hideho Okada,3,4 Sujan Shresta,5 Jeremy N. Rich,6,7,8 Pei-Yong Shi,2,9,10 Michael S. Diamond,1,11,12,13 and Milan G. Chheda1,14 Published November 24, 2020 Abstract: Glioblastoma multiforme (GBM) is a fatal human cancer in part because GBM stem cells are … Read more
Author Archives: cfriese
Biogenic metallic elements in the human brain?
James Everett, Frederik Lermyte, Jake Brooks, Vindy Tjendana-Tjhin, Germán Plascencia-Villa, Ian Hands-Portman, Jane M. Donnelly, Kharmen Billimoria, George Perry, Xiongwei Zhu, Peter J. Sadler, Peter B. O’Connor, Joanna F. Collingwood and Neil D. Telling Science Advances 09 Jun 2021: Vol. 7, … Read more
Thymic development of gut-microbiota-specific T cells
Abstract Humans and their microbiota have coevolved a mutually beneficial relationship, with the human host providing a hospitable environment for the microbes, and the microbiota providing many benefits including nutritional benefits and protection from pathogen infection1. Maintaining this relationship requires … Read more
NF1 mutation drives neuronal activity-dependent initiation of optic glioma
Nature, published online: 26 May 2021 Neurons have recently emerged as essential cellular constituents of the tumour microenvironment, and their activity has been shown to increase the growth of a diverse number of solid tumours. Although the role of neurons … Read more
Biomimetic nano drug delivery carriers for treating cardiovascular diseases
Key Points • Why do we need biomimicry? Which challenges does it aim to overcome? • Systemic delivery of free drugs has limitations. These limitations include rapid systemic clearance, inadequate levels of drug in the target tissue, poor solubility of … Read more
Synaptic communication in brain cancer
Abstract Increasing evidence indicates that the nervous system plays a critical role in cancer progression. This is particularly true in cancers that occur within the central nervous system. Communication between neurons and cancer cells is a fundamental component of brain … Read more
Groundbreaking study suggests COVID-19 virus might enter human brain
FEBRUARY 9, 2021 — UTSA scientists have discovered it might be possible for SARS-CoV-2, the virus that causes COVID-19, to enter the human brain. The research was led by Jenny Hsieh, professor of biology, director of the UTSA Brain Health Consortium and the Semmes Foundation … Read more
Scientists Discover How Remdesivir Works to Inhibit Coronavirus
Jan 28, 2021 Remdesivir is the only antiviral drug approved for use in the U.S. against COVID-19. Photo courtesy of Gilead. More effective antiviral treatments could be on the way after research from The University of Texas at Austin sheds … Read more
A protein that can melt tumors discovered at Vanderbilt
by Marissa Shapiro Jan. 27, 2021, 9:00 AM For the second time, cancer researchers at Vanderbilt have discovered a protein that—when genetically manipulated to impede it from interacting with a gene responsible for cancer genesis—effectively melts tumors in days. The article, “MYC … Read more
Monell Center Receives Kleberg Foundation Grant to Discriminate Bacterial and Viral Immune Responses to Reduce Antibiotic Use
PHILADELPHIA, January 18, 2021 – According to the Centers for Disease Control, nearly three million people will acquire an antibiotic-resistant infection each year in the United States. Doctors are currently overprescribing antibiotics for feverish individuals during the pandemic, despite widespread … Read more